Dr. McComb is a Research Associate Professor of Biochemistry at Boston University School of Medicine (BUSM) and is a faculty member of the BUSM Center for Biomedical Mass Spectrometry (CBMS). Dr. McComb has authored/co-authored more than 50 peer-review publications, reviews and textbook chapters and has over 200 conference proceedings including many as invited speaker. Dr. McComb has served as a panel member on several National committees, has served on several NIH peer review study sections and is an expert reviewer for NIH, NCI and other organizations. Dr. McComb is an active member of the Human Proteome Organization (HUPO) whose mission is to characterize the entire human proteome. Dr. McComb’s research aims are directed towards the identification and characterization of differentially expressed proteins and differentially observed peptides and post-translational modifications (PTMs) associated with markers of human disease with an emphasis directed towards cancer and cardiovascular disease. His laboratory focuses on applying mass spectrometry-based proteomics technology for the identification and characterization of proteins which may be perturbed by disease mechanism in-vivo with the aim to identify patterns of changes and PTM events in order to gain a global comprehensive understanding of disease progression. Identification of specific proteins and PTMs which change as a function of disease will lead to the development of diagnostic and prognostic biomarkers which will have tremendous clinical utility.
Representative Publications
-
Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O’Rourke B, Murphy A, Hart GW. Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res. 2016 Jul 1; 15(7):2254-64. PMID: 27213235.
-
Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. J Biol Chem. 2016 Jun 17; 291(25):12917-29. PMID: 27129262.
-
Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025. PMID: 26642319.
-
Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82. PMID: 26303906.
-
Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310. PMID: 26002792.
-
Yao C, Yu J, Taylor L, Polgar P, McComb ME, Costello CE. Protein Expression by Human Pulmonary Artery Smooth Muscle Cells Containing a BMPR2 Mutation and the Action of ET-1 as Determined by Proteomic Mass Spectrometry. Int J Mass Spectrom. 2015 Feb 15; 378:347-359. PMID: 25866469.
-
de Souza EE, Meirelles GV, Godoy BB, Perez AM, Smetana JH, Doxsey SJ, McComb ME, Costello CE, Whelan SA, Kobarg J. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res. 2014 Sep 5; 13(9):4074-90. PMID: 25093993.
-
Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87. PMID: 24469991.
-
Spencer JL, Bhatia VN, Whelan SA, Costello CE, McComb ME. STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post-Translational Modifications. Current Protocols in Bioinformatics. 2013; 22(13):1-36.
-
Spencer JL, Bhatia VN, Whelan SA, Costello CE, McComb ME. STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post-Translational Modifications. Curr Protoc Bioinformatics. 2013 Dec; 44:13.22.1-36. PMID: 25422678.
Complete list can be found at BU Profiles
