Manisha Mehta

M.D._2_2014

 

Education:

Year Degree Institution

Feb 1993               M.B.B.S                               University of Bombay, India

Jul 1996                MS                                       University of Bombay, India: Ophthalmology

Oct 2002              MRCOphth                       Royal College of Ophthalmology London University,

United Kingdom: Ophthalmology

 

Additional Training:

9/2003-10/2006      Post-doctoral fellowship, Harvard Medical School, Schepens Eye Research Institute, MA

7/2007-6/2008        Research Fellow in Oculoplastics, Harvard Medical School, Massachusetts Eye and Ear Infirmary (MEEI), MA

7/2008-6/2009        Fellow in Ocular Pathology, Harvard Medical School, MEEI, MA

7/2009-6/2010        Clinical Research Fellow in Ophthalmology, Massachusetts Eye Research and Surgery Institute, Cambridge, MA

      7/2010-6/2014        Resident in Pathology, Boston University School of Medicine (BUSM), MA

7/2014-6/2015        Fellow in Cytopathology, Harvard Medical School, Beth Israel Deaconess Medical Center (BIDMC), MA

      6/2015-5/2016        Fellow in Gastrointestinal pathology and Surgical pathology (combined), Harvard Medical School, BIDMC, MA

 

Academic Appointments:

7/2016-12/2019        Instructor, Harvard Medical School, Kohane Laboratory, Boston Children’s Hospital, MA

8/17/2018-current:    Assistant Professor, Dept. of Pathology & Laboratory Medicine, Boston University School of Medicine

Hospital Appointments or Other Employment:

7/2017-12/2017     Cytopathologist, Winchester Hospital, MA

Honors:

2/1992                       Honors in Ophthalmology and Otolaryngology at M.B.B.S, University of Bombay

5/1996                        Merit rank holder in M.S. Ophthalmology, University of Bombay

6/2014                        ‘Robert Foley’ award for Best Pathology Resident, Boston Medical Center, MA

Licenses and Certification:

5/2014   Massachusetts full medical license (257651)

6/2014   AP/CP board certified: American board of pathology (ABP)

9/2016   Cytology board certified: American board of pathology (ABP)

 

Teaching Experience and Responsibilities:

2008-2009: Weekly sessions in Ocular pathology for ophthalmology residents, MEEI, Boston, MA

2010-2014: Didactics in Neuropathology for medical students, BUSM, MA

2014-2016: Biweekly sessions in Cytology and GI pathology for pathology residents, BIDMC, Boston, MA

2018- current: Slide conferences and routine teaching for pathology residents, BMC, Boston, MA

 

 

Major Administrative Responsibilities:

2013-2014                   Chief resident, Pathology residency, BUSM, MA

Other Professional Activities:

Professional Societies: Memberships, Offices, and Committee Assignments:

2002   Royal College of Ophthalmologists, London, UK

2008   The Association for Research in Vision and Ophthalmology (ARVO)

2010   United States and Canadian Academy of Pathology (USCAP)

2010   Massachusetts Medical Society (MMS)

2014   College of American Pathologists (CAP)

Editorial Boards:

2008: Reviewer, Pediatrics

2009: Reviewer, Digital Journal of Ophthalmology

  1. : Reviewer, Ophthalmic Plastic and Reconstructive Surgery 
Current:
  2. Other Support:
2016-2020 NIH (2R01GM073626-11), Kohane laboratory, Boston Children’s Hospital

$1,710,945.00

Principal Investigator: Daniel Kohane, PhD, MD

Project: Prolonged duration local anesthesia of the ophthalmic nerve

Role: Key Personnel

 

Past:

2010-2014 Mallory grant, Boston Medical Center, Boston, MA
$5000

Principal Investigator: Nader Rahimi, PhD
Project: Identification of immunoglobulin containing and proline rich receptor-1(IGPR-1) as a novel cell adhesion molecule with a possible role in tumor development

Role: Key Personnel

Invited Lectures:

Regional/Local:        

Sept 2009 ‘Aspergillosis’

Department of Pathology, Tuft’s New England Medical Center, Boston, MA
Feb 2011 ‘Ocular adnexal IgG4-related sclerosing disease’

Department of Pathology & Laboratory Medicine, Boston Medical Center, MA
Sept 2015 ‘Vitreous cytology: A diagnostic glimpse into the eye’

Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA

 

 

Conference Presentations:

National:

 

Mar 2010

 ‘Identification of ubiquitin E3 ligase c-Cbl as a novel angiogenesis-suppressor protein’  United States and Canadian Academy of Pathology (USCAP), Washington DC

 
Oct 2013 ‘Vitreous cytology-A diagnostic glimpse into the eye’

American Association of Ophthalmic Oncologists and Pathologists (AAOOP), New Orleans, LA

 
Oct 2015 ‘Invasive carcinoma of the lacrimal drainage system’

Eastern Ophthalmic Pathology Society (EOPS), Cape Cod, MA

 
Oct 2018 ‘Rhabdomyosarcoma: The dreaded rapidly progressive orbital lesion’

Eastern Ophthalmic Pathology Society (EOPS), Washington DC

 

International:

Oct 2016 ‘A cyst with a twist: Conjunctival graft versus host disease’

Eastern Ophthalmic Pathology Society (EOPS), Nova Scotia, Canada

 

Bibliography:

 

Original, Peer Reviewed Articles:

  1. Mehta M, Adams G, Bunce C, Xing W, Hill M. Pilot study of the systemic effects of three different screening methods used for retinopathy of prematurity. Early Hum Dev. 2005 Apr;81(4):355-60.

 
  • Mehta M, Fay A. Squamous cell carcinoma of the eyelid and conjunctiva. International Ophthalmic Clinics (Winter) 2008;49(1):111-121.

 
  • Mehta M, Hernandez A, Fay A. Trigeminal dermatome distribution in patients with glaucoma and facial port wine stain. Dermatology. 2009;219(3):219-224.

 
  1. Husain D, Meyer RD, Chou E, Navruzbekov G, Ahmed E, Mehta M, Rahimi N. Role of c-Cbl dependent regulation of phospholipase C gamma1 activation in experimental choroidal neovascularization. Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6803-9.

 
  1. Mehta M, Foster CS. Histopathologic differential diagnosis of common eyelid lesions. Contemporary Ophthalmology. 2010.

 
  1. Nallaswamy N, Mehta M, Salas AH, Fay A. Statistics for Oculoplastic surgeons. Ophthal Plast Reconstr Surg. 2010 Mar-Apr; 26(2):71-5.

 
  • Mehta M, Mansfield T, VanderVeen D. The effect of topical anesthesia and age on pain scores in retinopathy of prematurity screening. J Perinatol. 2010 Nov; 30(11):731-5.

 

  • Osaki TH, Fay A, Mehta M, Nallaswamy N, Waner M, De Castro DK. Orbital development as a function of age in indigenous North American skeletons. Ophthal Plast Reconstr Surg. 2013 Mar-Apr;29(2):131-6.

 

 
  1. Mehta M, Rasheed RA, Duker J, Reichel E, Feinberg E, Husain D, Charles Foster CS, Laver N. Vitreous evaluation: A diagnostic challenge. Ophthalmology. 2015;122:531-537.

 
  1. Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H,   Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct;18(4):449-62.
12.  Wang YH, Meyer RD, Bondzie PA, Jiang Y, Rahimi I, Rezazadeh K, Mehta M, Laver NM,

Costello CE, Rahimi N. IGPR-1 is required for endothelial cell–cell adhesion and barrier function. J Mol Biol. 2016 Dec;428:5019-5033.

 

13. Weldon C, Ji T, Nguyen MT, Rwei A, Wang W, Hao Y, Zhao C, Mehta M, Wang BY, Tsui J, Marini RP, Kohane DS. Nanoscale Bupivacaine Formulations To Enhance the Duration and Safety of Intravenous Regional Anesthesia. ACS Nano. 2019 Jan 22;13(1):18-25.

 

14. Wang Y, Liu CH, Ji T, Mehta M, Wang W, Marino E, Chen J, Kohane DS.

Intravenous treatment of choroidal neovascularization by photo-targeted nanoparticles.

Nat Commun. 2019 Feb 18;10(1):804.

 

15. Yang R, Saarinen R, Okonkwo OS, Hao Y, Mehta M, Kohane DS.

Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media.

Mol Pharm. 2019 Apr 1;16(4):1555-1562.

 

16. Shomorony A, Santamaria CM, Zhao C, Rwei AY, Mehta M, Zurakowski D, Kohane DS. Prolonged Duration Local Anesthesia by Combined Delivery of Capsaicin- and Tetrodotoxin-Loaded Liposomes. Anesth Analg. 2019 Sep;129(3):709-717.

 

17. Shagan A, Zhang W, Mehta M, Levi S, Kohane DS, Mizrahi B. Hot Glue Gun Releasing Biocompatible Tissue Adhesive. Advanced Functional Materials. March 2019.https://doi.org/10.1002/adfm.201900998

 

 

18. Zhao C, Liu A, Santamaria CM, Shomorony A, Ji T, Wei T, Gordon A, Elofsson H, Mehta    M, Yang R, Kohane DS. Polymer-tetrodotoxin conjugates to induce prolonged duration local anesthesia with minimal toxicity. Nat Commun. 2019 Jun 12;10(1):2566.

 

19. Ross AE, Bengani LC, Tulsan R, Maidana DE, Salvador-Culla B, Kobashi H, Kolovou PE, Zhai H, Taghizadeh K, Kuang L, Mehta M, Vavvas DG, Kohane DS, Ciolino JB. Topical sustained drug delivery to the retina with a drug-eluting contact lens.Biomaterials. 2019 Oct;217:119285.

 

20. Woodruff AG, Santamaria CM, Mehta M, Pemberton GL, Cullion K, Kohane DS. Prolonged Duration Topical Corneal Anesthesia with the Cationic Lidocaine Derivative QX-314. Transl Vis Sci Technol. 2019 Oct 17;8(5):28.


Case Reports, Reviews, Chapters, and Editorials:

Textbook Chapters:

  1. Warner M, Mehta M, Jakobiec F. Squamous neoplasms of the conjunctiva.

In: Cornea (3rd edition) Mannis and Krachmer (ed). Saunders.2009.

 

  1. Mehta M, Laver N. Ocular Cytopathology

In: Manual of Practical Cytology, Springer. 2019.

Case Reports:

  1. Jakobiec FA, Mehta M, Sutula F. Keratinous cyst of the palpebral conjunctiva. Ophthal Plast Reconstr Surg. 2009 Jul-Aug;25(4):337-9.

 

  1. Mehta M, Jakobiec FA, Fay A. Idiopathic fibro-inflammatory disease of the face, eyelid and peri-orbital membrane with IgG4-positive plasma cells. Arch Pathol Lab Med. 2009 Aug; 133(8):1251-5.

 
3.      Mehta M, Waner M, Fay A. Amniotic membrane graft in the management of conjunctival vascular malformations. Ophthal Plast Reconstr Surg. 2009 Sep-Oct; 25(5):371-5.

 
  1. Jakobiec FA, Mehta M, Iwamoto M, Hatton M, Thakker M, Fay A. Intratarsal keratinous cysts of the meibomian gland: distinctive clinicopathologic and immunohistochemical features in six cases. Am J Ophthalmol 2010 Jan; 149(1):82-94.

 

5.      Jakobiec FA, Mehta M, Greenstein SH, Colby K. The white caruncle: sign of a keratinous cyst   arising from a sebaceous gland duct. Cornea. 2010 Apr;29(4):453-5.

 
  1. Jakobiec FA, Stacy RC, Mehta M, Fay A. IgG4-positive dacryoadenitis and küttner submandibular sclerosing inflammatory tumor. Arch Ophthalmol. 2010 Jul;128(7):942-4.

 

  1. Mehta M, Dacey M, Foster CS. Recurrent conjunctivitis and scleritis secondary to coexistent conjunctival pemiphigus vulgaris and cryptic herpes simplex infection: a case report. Ocul Immunol Inflamm. 2010 Dec; 18(6):454-6.

 

  1. Mehta M, Siddique S, Foster CS. Immunohistochemical differences between normal and chronically inflamed conjunctiva: diagnostic features. Am J Dermatopathol. 2011 Dec;33(8):786-9.

 

  1. 20.See comment in PubMed Commons below Gale HI, Setty BN, Sprinz PG, Doros G, Williams DD, Morrison TC, Kalajian TA, Tu P,       Mundluru SN, Mehta M, Castro-Aragon I. Implications of radiologic-pathologic correlation for gallbladder disease in children and young adults with sickle cell disease. Emerg Radiol. 2015 Oct; 22(5):543-51.

 

  1. Grunwald D, Mehta M, Sheth SG. Pseudomembranous Collagenous Colitis: A Case of Not-so-                       Microscopic Colitis. ACG case reports journal, 2016.