Neurocritical Care

The Division of Neurocritical Care provides care for critically ill patients with a wide variety of neurologic emergencies.  Our research parallels illnesses most frequently affecting our patient population with a focus on brain death, coma post-cardiac arrest, traumatic brain injury, neurologic infections including COVID-19 and infectious endocarditis, and development of tools for early identification of patients with secondary decline.  In addition we participate in acute stroke and epilepsy clinical trials. 

Current Research

Neurologic Infections (PI: Anna Cervantes)

  • COVID 19
    Characterizing acute neurologic complications of hospitalized patients with COVID-19
    Observational study of recovery post-COVID (Post-Acute Sequelae of COVID-19) as part of a Boston consortium
  • Infectious Endocarditis (collaboration with CT surgery, cardiology, infectious disease, and addiction medicine)
    Characterizing neurologic complications in tricuspid valve disease
    Investigating acute stroke treatment options for IE related stroke
    Seizures during IE and epilepsy in IE survivors
  • Infection in Hospitalized patients with acute severe traumatic brain injury (collaboration with NCC, Neurosurgery, and Trauma Surgery/Surgical Critical Care) (PI: Ali Daneshmand)

Medical Ethics in the ICU (PI: Anna Cervantes)

  • Evaluation of Crisis Standards of Care triage protocols for determining allocation of limited resources

Outcomes following Cardiac Arrest (PI: David Greer)

    • MOCA – advanced MRI and EEG techniques to help determine recovery of arousal post-cardiac arrest
    • MOCHA/SPARE – cooperative study with Brazil looking at the impact of withdrawal of life-sustaining therapy on outcomes and prognostic tool performance

    Brain Death (PI: David Greer)

    • New England Brain Death Database – a national database for collecting brain death cases prospectively and retrospectively to answer the many remaining questions in brain death

      Dynamic Risk Prediction of Life threatening Mass Effect (PI: Charlene Ong)

      • Retrospective dynamic models of life threatening mass effect after ischemic stroke
      • Prospective dynamic models using Quantitative Pupillometry

      LTME Risk Prediction Automated Email (PI: Charlene Ong)

      • Obtain survey feedback on automated emails calculating risk of EDEMA to clinical providers (IRB approved, not started yet)

      Oculography (PI: Charlene Ong)

      • Automated eye movement detection algorithm using sleep study EOG
      • Enrollment of comatose cardiac arrest patients to determine qualitative eye movements and recovery potential

      Pupillometry (PI: Charlene Ong)

      • Midbrain Compression and Pupillometry: Test the association of quantitative pupil markers and quantitative midbrain compression in large stroke and intraparenchymal hemorrhage
      • Examination of associations between analgosedatives and quantitative pupillometry
      • Case series of pre and post quantitative pupil metrics and hemicraniectomy

      Subarachnoid Hemorrhage (PI: David Chung)

      • Reducing complications and optimizing outcomes in hospitalized patients following brain aneurysm rupture
      • The role of cortical spreading depolarizations in injury progression in subarachnoid hemorrhage and trauma
      • Functional connectivity and long term cognitive deficits following subarachnoid hemorrhage and trauma
      • Non-invasive cerebral blood flow determination in acutely brain injured patients

      Perihematomal edema (PHE) in the setting of spontaneous intracranial hemorrhage (ICH) (PI: Courtney Takahashi)

      • Developing and refining a semi-automated computer program to accurately measure PHE volumes 
      • Determining if PHE volumes correlate with outcomes (e.g. mRS) 
      • Determining the natural history of PHE development and abatement over time 
      • Overall goal is to evaluate the utility of PHE as a biomarker and possible intervention point to improve outcomes in ICH 

      Neurocritical Care Nursing education (PI: Courtney Takahashi)

      • Developing modern learning techniques (e.g. small group evaluation) and applying them to see if they can help with improved retention and synthesis. Topics include neuroanatomy, case based scenarios, and imaging. 

      Traumatic Brain Injury (collaboration with NCC, Neurosurgery, and Trauma Surgery/Surgical Critical Care) (PI: Ali Daneshmand)

      • Impact of infections on outcomes in TBI
      • Prognostication models in TBI

      Status Epilepticus

      • RAISE – a randomized, double-blind, placebo-controlled trial that will evaluate the efficacy and safety of IV ganaxolone in RSE
      Research Faculty:

      Anna Cervantes-Arslanian, MD
      David Greer, MD, MA
      Courtney Takahashi, MD, MCR
      Charlene Ong, MD, MPHS
      David Chung, MD, PhD
      Ali Daneshmand, MD, MPH
      Kushak Suchdev, MD 

      Grants:

      David Chung (Chung Lab):

      • Non-Invasive Blood Flow to Predict Recovery from Coma in Brain Injured Patients (CTSI Pilot award 2021)

      Charlene Ong:

      • Peter Paul Career Development Award                                                                            
      • Grinspoon Family Junior Faculty Research Award
      • K23NS116033, Dynamic Risk Prediction of Life Threatening Mass Effect after Ischemic Stroke

      David Greer:

      • R01NS102574 – Multimodal network connectivity architecture (MOCA) of the brain and its role in the recovery of consciousness in comatose cardiac arrest patients
      Selected Publications:
      • Takahashi, CE; Brambrink AM, Aziz MF, Macri E, Raines J, Multani-Kohol A, Hinson HE, Lutsep HL, Clark WM, Fields, J. Association of intraprocedural blood pressure and end tidal carbon dioxide with outcome after acute stroke intervention.  Neurocritical Care, 2014: 202-208.  PMID 24114519
      • Sweeney EM, Thakur KT, Lyons JL, Smith BR, Willey JZ, Cervantes-Arslanian AM, Hickey MK, Uchino K, Haussen DC, Koch S, Schwamm LH, Elkind MS, Shinohara RT, Mateen FJ. Outcomes of intravenous tissue plasminogen activator for acute ischaemic stroke in HIV-infected adults. Eur J Neurol. 2014 Jul 10. PMID: 25040336
      • Ong CJ, Dhand A, Diringer MN. Early withdrawal decision making in patients with coma after cardiac arrest: a qualitative study of intensive care clinicians. Neurocritical Care 2016;25(2):258-65. PMID 27112149
      • Burns JD, Rindler RS, Carr C, Lau H, Cervantes-Arslanian AM, Green-LaRoche DM, Salem R, Kase CS. Delay in Diagnosis of Basilar Artery Stroke. Neurocrit Care. 2016 Apr; 24(2):172-9. PMID: 26503513
      • Chung DY, Oka F, Ayata C. Spreading Depolarizations: A Therapeutic Target Against Delayed Cerebral Ischemia After Subarachnoid Hemorrhage. J Clin Neurophysiol. 2016 Jun; 33(3):196-202. PMID: 27258442.
      • Chung DY, Claassen J, Agarwal S, Schmidt JM, Mayer SA. Assessment of Noninvasive Regional Brain Oximetry in Posterior Reversible Encephalopathy Syndrome and Reversible Cerebral Vasoconstriction Syndrome. J Intensive Care Med. 2016 Jul; 31(6):415-9. PMID: 26732768.
      • Mukerji SS, Misra V, Lorenz D, Cervantes-Arslanian AM, Lyons J, Chalkias S, Wurcel A, Burke D, Venna N, Morgello S, Koralnik IJ and Gabuzda D. Temporal Patterns and Drug Resistance in CSF Viral Escape Among ART-Experienced HIV-1 Infected Adults. J Acquir Immune Defic Syndr. 2017;75:246-255. PMID: 28328546
      • Ong CJ, Gluckstein JA, Laurido-Soto O, Yan Y, Dhar R, Lee JM. Enhanced detection of edema in malignant anterior circulation stroke (EDEMA) score: A risk prediction tool. Stroke 2017;48(7):1969-72. PMID: 2847333
      • AbdelRazek MA, Gutierrez J, Mampre D, Cervantes-Arslanian A, Ormseth C, Haussen D, Thakur KT, Lyons JL, Smith BR, O’Connor O, Willey JZ, Mateen FJ. Intravenous Thrombolysis for Stroke and Presumed Stroke in Human Immunodeficiency Virus-Infected Adults: A Retrospective, Multicenter US Study. Stroke 2018 Jan;49(1):228-231. PMID:29273597
      • Chung DY, Sugimoto K, Fischer P, Böhm M, Takizawa T, Sadeghian H, Morais A, Harriott A, Oka F, Qin T, Henninger N, Yaseen MA, Sakadžic S, Ayata C. Real-time non-invasive in vivo visible light detection of cortical spreading depolarizations in mice. J Neurosci Methods. 2018 11 01; 309:143-146. PMID: 30194041.
      • Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci Rep. 2019 11 26; 19(12):94. PMID: 31773310.
      • Chung DY, Sadeghian H, Qin T, Lule S, Lee H, Karakaya F, Goins S, Oka F, Yaseen MA, Houben T, Tolner EA, van den Maagdenberg AMJM, Whalen MJ, Sakadžic S, Ayata C. Determinants of Optogenetic Cortical Spreading Depolarizations. Cereb Cortex. 2019 03 01; 29(3):1150-1161. PMID: 29425263.
      • Ong CJ, Hutch M, Smirnakis SM. The Effect of Ambient Light Conditions on Quantitative Pupillometry. Neurocrit Care 2019;30(2):316-321. PMID 30218349
      • Ong CJ, Hutch M, Barra M, Kim A, Zafar S, Smirnakis SM. Osmotic therapy effects on pupil reactivity: Quantification using pupillometry in critically ill neurologic patients. Neurocrit Care 2019;30(2):307-315. PMID 30298336
      • Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci 2019 11 26; 19(12):94. PMID: 31773310.
      • Ibrahim MS, Samuel B, Mohamed W, Suchdev K. Cardiac Dysfunction in Neurocritical Care: An Autonomic Perspective. Neurocrit Care. 2019 06; 30(3):508-521. PMID: 30484009
      • Chung DY, Olson DM, John S, Mohamed W, Kumar MA, Thompson BB, Rordorf GA. Evidence-Based Management of External Ventricular Drains. Curr Neurol Neurosci Rep. 2019 11 26; 19(12):94. PMID: 31773310.
      • Malak, W; Qureshi MM; Kiliany, R; Brahmbhatt, TS; Mian AZ and Takahashi, CE. Contribution of Brain MRI after Head CT in the Evaluation of Acute, Hospitalized Traumatic Brain Injury Patients: An Under-Utilized Resource? Biomedical Journal of Scientific & Technical Research, March 2020: 20264-20269. DOI: 10.26717/BJSTR.2020.26.004408
      • Cervantes-Arslanian A*, Lau, V*, Anand P, Shulman J, Ford T, Takahashi C, Daneshmand A, Nguyen T, Suchdev K, Abdennadher M, Saxena A, Macone A, Perloff M, Zhu S, Greer M. Rapid Development and Dissemination of Protocols for Managing Neurology Inpatients with COVID-19. Ann Neurol. 12 May 2020. PMID: 32395831.
      • Moloney PB, Hutchinson S, Heskin J, Mulcahy F, Langan Y, Conlon NP, Linas BP, Takahashi C, Cervantes-Arslanian AM. Possible N-methyl-D-aspartate receptor antibody-mediated encephalitis in the setting of HIV cerebrospinal fluid escape. J Neurol. 2020 May; 267(5):1348-1352. PMID: 31960135
      • Shulman J, Jara H, Qureshi M, Lau H, Finn B, Abbas S, Cervantes-Arslanian AM, Mercado M, Greer D, Chapman M, Mian A, Takahashi CE. Perihematomal Edema Surrounding Spontaneous Intracerebral Hemorrhage by CT: Ellipsoidal vs. Morphometric Volumetry. Medicine (Baltimore). 2020 Jul 10;99(28):e20951. PMID: 32664097
      • Anand P, Zakaria A, Benameur K, Ong C, O’Shea S, Putnam M, Greer D, Cervantes-Arslanian AM. Myoclonus in Patients with COVID-19: A Multicenter Case Series. Crit Care Med. 2020 Aug 14. PMID: 32804784
      • Nwajei F, Anand P, Abdalkader M, Andreu Arasa VC, Aparicio HJ, Behbahani S, Curiale G, Daneshmand A, Dasenbrock H, Mayo T, Mian A, Nguyen T, Ong C, Romero JRR, Sakai O, Takahashi C, Cervantes-Arslanian AM. Cerebral Venous Sinus Thromboses in Patients with SARS-Co-V Infection: Three Cases and a Review of the Literature. J Stroke Cerebrovasc. Dis. 2020. PMID: 33254367
      • Greer DM, Shemie SD, Lewis A, Torrance S, Varelas P, Goldenberg FD, Bernat JL, Souter M, Topcuoglu MA, Alexandrov AW, Baldessari M, Bleck T, Citerio G, Dawson R, Hoppe A, Jacobe S, Manara A, Nakagawa TA, Pope TM, Silvester W, Thomson D, Al Rahma H, Badenes R, Baker AJ, Cerny V, Chang C, Chang TR, Gnedovskaya E, Han, M, Honeybul S, Jimenez E, Kuroda Y, Liu G, Mallick UK, Marquevich V, Mejia-Mantilla J, Piradov M, Quayyum S, Shrestha GS, Su Y, Timmons SD, Teitelbaum J, Videtta W, Zirpe K, Sung G. Determination of brain death/death by neurologic criteria around the world: the world brain death project. JAMA 2020 Sep 15;324(11):1078-1097.
      • Migady I, Rae-Grant A, Greer DM. Brain death evaluation during the pandemic. Neurology. 2020 Oct 13;95(15);693-4.
      • Sharma M, Creutzfeldt CJ, Lewis A, Patel PV, Hartog C, Jannotta GE, Blissitt P, Kross EK, Kassenbaum N, Greer DM, Curtis JR, Wahlster S. Healthcare professionals’ perceptions of critical care resources availability and factors associated with mental well-being during COVID-19: Results from a US survey. Clin Infect Dis 2020; Sep 2 [Epub ahead of print]
      • Anand P and Lau K.H. V, Chung D, Virmani D, Cervantes-Arslanian A, Mian A and Takahashi CE. Posterior Reversible Encephalopathy Syndrome in Patients with Coronavirus Disease 2019: Two Cases and a Review of The Literature. J Stroke Cerebrovasc Dis. 2020 Nov; 29 (11): 105212
      • Carneiro T, Dashkoff J, Leung LY, Nobleza COS, Marulanda-Londono E, Hathidara M Koch S, Sur N, Boske A, Voetsch B, Nour HA, Miller DJ,  Daneshmand A, Shulman J, Curiale G, Greer DM, Romero JR, *Anand P, *Cervantes-Arslanian AM. Intravenous tPA for Acute Ischemic Stroke in Patients with COVID-19. J Stroke Cerebrovasc. Dis. 2020 Nov;29 (11): 105201. Epub 2020 Jul 27. PMCID: PMC7383245
      • Ong CJ, Orfanoudaki A, Zhang R, Caprasse FPM, Hutch M, MA L, Fard D, Balogun O, Miller M, Minnig M, Saglam H, Prescott B, Greer D, Smirnakis SM, Bertsimas D. Machine Learning and Natural Language Processing Methods to Identify Ischemic Stroke, Acuity and Location from Radiology Reports. Plos One. 2020;15(6): e0234908. PMID 32559211
      • Sugimoto K, Chung DY. Spreading Depolarizations and Subarachnoid Hemorrhage. Neurotherapeutics. 2020 04; 17(2):497-510. PMID: 32323204.
      • Janeway M; Zhao X; Rosenthaler M; Zuo Y; Balasubramaniyan K; Poulson M; Neufeld M, Siracuse J, Takahashi CE, Allee L; Dechert T; Burke P; Li F, Kalesan B. Clinical diagnostic phenotypes in hospitalization due to self-inflicted firearm injury. J Affect Disord. 2020 Sep 15; 278: 172-180. DOI: 10.1016/j.jad.2020.09.067
      • Anand P, Zhou L, Bhadelia N, Hamer DH, Greer DM, Cervantes-Arslanian AM. Neurologic Findings Among Inpatients With COVID-19 at a Safety-net US Hospital. Neurol Clin Pract. 2021 Apr; 11(2):e83-e91. PMID: 33842075.
      • Sader E, Abdalkader M, Thom N, Nguyen TN, McDonald S, Greer D, Brown SC, Mohamedali A, Gutierrez J, Shi H, Morris J, Lopez-Rivera V, Sheth SA, Sloane KL, Singhal A, Atchaneeyasakul K, Liebeskind DS, Khandelwal P, Bach I, Raz E, Cervantes-Arslanian AM. Endovascular Treatment of Infective Endocarditis-Related Acute Large Vessel Occlusion Stroke. J Stroke Cerebrovasc Dis. 2021 Apr 08; 30(6):105775. PMID: 33839380
      • Nadjarian A, LeClair J, Mahoney TF, Awtry EH, Bhatia JS, Caruso LB, Clay A, Greer D, Hingorani KS, Horta LFB, Ibrahim M, Ieong MH, James T, Kulke MH, Lim R, Lowe RC, Moses JM, Murphy J, Nozari A, Patel AD, Silver B, Theodore AC, Wang RS, Weinstein E, Wilson SA, Cervantes-Arslanian AM. Validation of a Crisis Standards of Care Model for Prioritization of Limited Resources During the Coronavirus Disease 2019 Crisis in an Urban, Safety-Net, Academic Medical Center. Crit Care Med. 2021 Jun 09. PMID: 34115635.
      • Carneiro T, Spears W, LeClair J, Mahoney T, Takahashi C, Cervantes-Arslanian A. Admission Lymphocytopenia is Associated with Urinary Tract Infection and Nosocomial Infections in Hemorrhagic Stroke. J Stroke Cerebrovasc Dis. 2021 Sep 03; 30(11):106079. PMID: 34488005.
      • Arandela K, Samudrala S, Abdalkader M, Anand P, Daneshmand A, Dasenbrock H, Nguyen T, Ong C, Takahashi C, Shulman J, Babi MA, Sivakumar S, Shah N, Jain S, Anand S, Nobleza COS, Shekhar S, Venkatasubramanian C, Salahuddin H, Taqi MA, Nour HA, Nofar JB, Cervantes-Arslanian AM. Reversible Cerebral Vasoconstriction Syndrome in Patients with Coronavirus Disease: A Multicenter Case Series. J Stroke Cerebrovasc Dis. 2021 Sep 17; 30(12):106118. PMID: 34560378.
      • Sasanejad P, Hezarkhani LA, Arsang-Jang S, Tsivgoulis G, Ghoreishi A, Kristian B, Rahmig J, Farhoudi M, Hokmabadi ES, Borhani-Haghighi A, Sariaslani P, Sharifi-Razavi A, Ghandehari K, Khosravi A, Smith C, Nilanont Y, Akbari Y, Nguyen TN, Bersano A, Yassi N, Yoshimoto T, Lattanzi S, Gupta A, Zand R, Rafie S, Mousavian SP, Shahsavaripour MR, Amini S, Kamenova SU, Kondybayeva A, Zhanuzakov M, Macri EM, Nobleza COS, Ruland S, Cervantes-Arslanian AM, Desai MJ, Ranta A, Ahmadi AM, Rostamihosseinkhani M, Foroughi R, Hooshmandi E, Akhoundi FH, Shuaib A, Liebeskind, DS, Siegler J, Romano JG, Mayer SA, Shahripour RB, Zamani B, Woolsey A, Fazli Y, Mojtaba K, Isaac CF, Biller J, Di Napoli M, Azarpazhooh MR. Safety and Outcomes of Intravenous Thrombolytic Therapy in Ischemic Stroke Patients with COVID-19: CASCADE Initiative, J Stroke Cerebrovasc Dis. 30(12). 2021.
      • Sreekrishnan A, Ong CJ, Mahajan R, Prescott B, Smirnakis SM, Bevers MB, Feske SK, Snider SB. Subcortical Sparing Associated with Ambulatory Independence after Hemicraniectomy for Malignant Infarction. J Stroke Cerebrovasc Dis. 2021;30(8):1015850. PMID: 34000606.
      • Prescott BR, Saglam H, Duskin J, Miller MI, Thakur AS, Gholap EA, Hutch MR, Smirnakis SM, Zafar SF, Dupuis J, Benjamin EJ, Greer DM, Ong CJ. Anisocoria and Poor Pupil Reactivity by Quantitative Pupillometry in Patients with Intracranial Pathology. Critical Care Medicine, 2021. doi: 10.1097/CCM.0000000000005272.
      • Chung DY, Thompson BB, Kumar MA, Mahta A, Rao SS, Lai JH, Tadevosyan A, Kessler K, Locascio JJ, Patel AB, Mohamed W, Olson DM, John S, Rordorf GA. Association of External Ventricular Drain Wean Strategy with Shunt Placement and Length of Stay in Subarachnoid Hemorrhage: A Prospective Multicenter Study. Neurocrit Care. 2021 Sep 08. PMID: 34498207.
      • Bernier TD, Schontz MJ, Izzy S, Chung DY, Nelson SE, Leslie-Mazwi TM, Henderson GV, Dasenbrock H, Patel N, Aziz-Sultan MA, Feske S, Du R, Abulhasan YB, Angle MR. Treatment of Subarachnoid Hemorrhage-associated Delayed Cerebral Ischemia With Milrinone: A Review and Proposal. J Neurosurg Anesthesiol. 2021 Jul 01; 33(3):195-202. PMID: 33480639.
      • Chung DY, Abdalkader M, Nguyen TN. Aneurysmal Subarachnoid Hemorrhage. Neurol Clin. 2021 05; 39(2):419-442. PMID: 33896527.
      • Chung DY, Oka F, Jin G, Harriott A, Kura S, Aykan SA, Qin T, Edmiston WJ, Lee H, Yaseen MA, Sakadžic S, Boas DA, Whalen MJ, Ayata C. Subarachnoid hemorrhage leads to early and persistent functional connectivity and behavioral changes in mice. J Cereb Blood Flow Metab. 2021 05; 41(5):975-985. PMID: 32936728.
      • Lau KHV, Hamlyn E, Williams TJ, Qureshi MM, Mak K, Mian A, Cervantes-Arslanian A, Zhu S, Takahashi C. The Effects of Video Instruction on Neuroscience Intensive Care Unit Nursing Skills in Case Presentations and Neurological Examinations. J Neurosci Nurs. 2021 Apr 08. PMID: 33840806.
      • Lau KHV, Anand P, Greer DM, Cervantes-Arslanian A, Phicil S, Moore J, Takahashi C. Leveraging Trends in Neurology Admissions for Departmental Planning During the COVID-19 Pandemic. 2021 Apr; 11(2):125-130. PMID: 33791055.
      • Zhou SE, Barden MM, Gilmore EJ, Pontes-Neto OM, Sampaio Silva G, Kurtz P, Oliveira-Filho J, Cougo-Pinto PT, Zampieri FG, Napoli NJ, Theriot JJ, Greer DM, Maciel CB. Postcardiac arrest neuroprognostication practices: A survey of Brazilian physicians. Crit Care Explor 2021 Jan 11;3(1):e0321.
      • Greer DM, Moeller J, Torres DR, Soni M, Cruz S, Tornes L, Patwa H, Gutmann L, Sacco R, Galetta S. Funding the educational mission in neurology. Neurology 2021 Mar 23;96(12):574-82.
      • Greer DM, Ritter J, Helbok R, Badjatia N, Ko SB, Guanci M, Sheth KN. Impact of Fever Prevention in Brain-Injured Patients (INTREPID): Study Protocol for a Randomized Controlled Trial. Neurocrit Care 2021 Mar 24 [Online ahead of print]
      • Lewis A, Kumpfbeck A, Liebman J, Shemie SD, Sung G, Torrance S, Greer D. Barriers to the Use of Neurologic Criteria to Declare Death in Africa. Am J Hosp Palliat Care. 2021 Mar 30 [Online ahead of print]
      • Migdady I, Amin M, Shoskes A, Hassett C, Rae-Grant A, Snider SB, Greer DM, Cho SM, George P. Outcomes, Time-Trends, and Factors Associated with Ancillary Study Use for the Determination of Brain Death. Crit Care Med 2021 Apr 12 [Online ahead of print]
      • Francoeur C, Weiss MJ, Macdonald JM, Press C, Greer DM, Berg RA, Topjian AA, Morrison W, Kirschen MP. Variability in Pediatric Brain Death Determination Protocols in the United States. Neurology 2021 May 28 [Online ahead of print]
      • Beekman R, Maciel CB, Ormseth CH, Zhou SE, Galluzzo D, Miyares LC, Torres-Lopez VM, Payabvash S, Mak A, Greer DM, Gilmore EJ. Early head CT in post-cardiac arrest patients: a helpful tool or contributor to self-fulfilling prophecy? Resuscitation. 2021 Aug;165:68-76.
      • Kurtz P, Storm C, Soares M, Bozza F, Maciel CB, Greer DM, Bastos LSL, Melo U, Mazza B, Santino MS, Seabra Lannes R, de Moraes APP, Passos JT, Moralez GM, Santos RC, Machado MM, Saturnino SF, Mendes CL, Oswaldo Vianna A, Salluh J. Clinical Characteristics and In-Hospital Mortality of Cardiac Arrest Survivors in Brazil: A Large Retrospective Multicenter Cohort Study. Crit Care Explor. 2021 Jul 14;3(7):e0479.
      • Farris C, Baghdanian A, Takahashi CE, Sung E, Sakai O, Patel MN, Burley H, Rai Aayushi, Brahmbhatt T, Adran D, Kim H, Ravilla A, Mian A.  Implementation of Institutional Triaging Algorithms Decreases Head and Neck MDCT Usage in Blunt Trauma.  Radiology (Accepted, in press).
      • Zhou SE, Barden MM, Gilmore EJ, Pontes-Neto OM, Sampaio Silva G, Kurtz P, Oliveira-Filho J, Cougo-Pinto PT, Zampieri FG, Napoli NJ, Theriot JJ, Greer DM, Maciel CB. Postcardiac arrest neuroprognostication practices: A survey of Brazilian physicians. Crit Care Explor 2021 Jan 11;3(1):e0321.
      • Charidimou A, Samudrala S, Cervantes-Arslanian AM, Sloan JM, Dasenbrock HH, Daneshmand A. Vaccine-Induced Immune Thrombotic Thrombocytopenia with Concurrent Arterial and Venous Thrombi Following Ad26.COV2.S Vaccination. J Stroke Cerebrovasc Dis. 2021 Sep 18; 30(12):106113.PMID: 34547677