Giovanni Ligresti, PhD
Assistant Professor of Medicine
Graduate Education: University of Udine, Udine, Italy. PhD in Biomedical Sciences and Biotechnology
Post-doctoral Fellowship: University of Washington, Seattle, WA, (Tissue injury and Angiogenesis, kidney fibrosis), Mayo Clinic, Rochester, MN, (Lung injury and fibrosis)
Research Interests:
- Lung injury and fibrosis
- Epigenetic mechanisms in fibroblast biology
- Vascular remodeling in lung regeneration
Dr. Ligresti is an Assistant Professor in the Department of Medicine at Boston University School of Medicine (Pulmonary center and Arthritis center). His research focuses on tissue injury and fibrosis with specific emphasis on pathological mechanisms driving lung fibrosis including altered epigenetic programs contributing to sustained fibroblast activation during lung fibrogenesis. Additionally, his lab is interested in investigating molecular mechanisms leading to mitochondrial dysfunction in fibroblasts and endothelial cells during aging as well as understanding how these alterations contribute to lung fibrosis progression.
Selected Publications:
Caporarello N, Meridew JA, Jones DL, Tan Q, Haak AJ, Choi KM, Manlove LJ, Prakash YS, Tschumperlin DJ, Ligresti G. PGC1α repression in IPF fibroblasts drives a pathologic metabolic, secretory and fibrogenic state. Thorax. 2019 Aug;74(8):749-760.
Ligresti G, Caporarello N, Meridew JA, Dakota JL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, YS Prakash, Lomberk G, Urrutia RA, Tschumperlin DJ. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI Insight. 2019 May 16;5.
Tan Q, Ma XY, Liu W, Meridew JA, Jones DL, Haak AJ, Sicard D, Ligresti G, Tschumperlin DJ. Nascent Lung Organoids Reveal Epithelium-and BMP-Mediated Suppression of Fibroblast Activation. Am J Respir Cell Mol Biol. 2019 May 3
Jones DL, Ligresti G. Survivin IPF: Targeting Cellular Metabolism to Promote Apoptosis in IPF Fibroblasts. Am J Respir Cell Mol Biol. 2019 Jan;60(1):5-6.
Tschumperlin DJ, Ligresti G, Hilscher MB, Shah VH. Mechanosensing and fibrosis. J Clin Invest. 2018 Jan 2;128(1):74-84.
Schafer MJ, White TA, Iijima K, Haak AJ, Ligresti G, Atkinson EJ, Oberg AL, Birch J, Salmonowicz H, Zhu Y, Mazula DL, Brooks RW, Fuhrmann-Stroissnigg H, Pirtskhalava T, Prakash YS, Tchkonia T, Robbins PD, Aubry MC, Passos JF, Kirkland JL, Tschumperlin DJ, Kita H, LeBrasseur NK. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 2017; Feb 23; 8:14532.
Dang LT, Aburatani T, Marsh G, Johnson B, Alimperti S, Yoon CJ, Huang A, Szak S, Nakagawa N, Gomez I, Ren S, Read SK, Sparages C, Aplin AC, Nicosia RF, Chen C, Ligresti G, Duffield JS. Hyperactive FOXO1 results in lack of tip stalk identity and deficient microvascular regeneration during kidney injury. Biomaterials2017; Oct; 141:314-329.
Ligresti G, Nagao RJ, Xue J, Choi YJ, Xu J, Ren S, Aburatani T, Anderson SK, MacDonald JW, Bammler TK, Schwartz SM, Muczynski KA, Duffield JS, Himmelfarb J, Zheng Y. A Novel Three-Dimensional Human Peritubular Microvascular System. J Am Soc Nephrol. 2016; Aug; 27(8):2370-81.
Complete list of publications on PubMed