Paul J. Maglione, M.D., Ph.D.
Faculty and Fellows
Assistant Professor of Medicine
BU Profile for Dr. Maglione
Medical School: Albert Einstein College of Medicine
Residency: Mount Sinai (Internal Medicine)
Fellowship: Mount Sinai (Allergy and Immunology)
Special Interests
Research:
- Impact of B cell maturation defects upon disease
- Role of B cell activating factor
- Mechanisms of cytokine dysregulation in primary immunodeficiency
- Lung disease and other complications of common variable immunodeficiency
Clinical:
- Antibody deficiency
- Common variable immunodeficiency and related complications
- Primary and secondary immunodeficiency
- Recurrent infections
PJ Maglione, MD, PhD is a physician-scientist in the Pulmonary Center of Boston University School of Medicine. His research efforts in the areas of primary antibody deficiency and B cell biology have been supported by numerous sources including the Thrasher Research Fund, Clinical Immunology Society, Primary Immune Deficiency Treatment Consortium, American Association of Allergy, Asthma and Immunology, and the National Institutes of Health. Dr. Maglione studies human B cell biology, particularly in how it relates to and is informed by primary immunodeficiency disorders. His research program utilizes high throughput strategies such as RNA sequencing, B cell receptor repertoire analysis, and seromics together with cell culture, immunofluorescence, and information from the patient medical record to conduct bedside-to-bench studies on immunodeficiency disorders.
In addition to running a research laboratory, Dr. Maglione provides clinical care for patients with immunodeficiency disorders and has particular interest and expertise in common variable immunodeficiency (CVID) and its related complications, including chronic lung disease. His publications include identification of novel biomarkers and treatment of CVID interstitial lung disease.
Selected Publications
- P. J Maglione, G. Gyimesi, M. Cols, L. Radigan, H. M. Ko, T. Weinberger, B. H. Lee, E. K. Grasset, A. H. Rahman, A. Cerutti, C. Cunningham-Rundles. 2019. BAFF-driven B cell hyperplasia underlies lung disease in common variable immunodeficiency. JCI Insight. In press.
- E. Schussler, M. B. Beasley, and P. J. Maglione. 2016. Lung disease in primary antibody deficiency. J Allergy Clin Immunol Pract. 4: 1039-1052.
- P. J. Maglione. 2016. Autoimmune and lymphoproliferative complications of common variable immunodeficiency. Curr Allergy Asthma Rep. 16: 19. doi: 10.1007/s11882-016-0597-6.
- P. J. Maglione, J. R. Overbey, C. Cunningham-Rundles. 2015. Progression of CVID Interstitial Lung Disease Accompanies Distinct Pulmonary and Laboratory Findings. J Allergy Clin Immunol Pract. 3: 941-50.
- P. J. Maglione, N. Simchoni, S. Black, L. Radigan, J. R. Overbey, E. Bagiella, J. B. Bussel, X. Bossuyt, J-L. Casanova, I. Meyts, A. Cerutti, C. Picard, and C. Cunningham-Rundles. 2014. IRAK- and MyD88- deficiencies impair IgM responses against T-independent bacterial antigens in humans. Blood. 124: 3561-3571.
- P. J. Maglione, H. M. Ko, M. B. Beasley, J. A. Strauchen, and C. Cunningham-Rundles. 2013. Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in CVID. J Allergy Clin Immunol. 133: 535-542.
Links